Zinc and sperm motility

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10 Ways to Boost Male Fertility and Increase Sperm Count

Zinc: A small molecule with a big impact on sperm function

At ejaculation, human sperm are considered to be mechanically trapped and become immotile in the semen coagulum by binding to semenogelins Sgs from the seminal vesicle and zinc ions from the prostate. However, the physiological combined roles of the protein and heavy metal on sperm motility are unknown. Here, we have first demonstrated that Sg I alone, which does not form the semen coagulum without zinc, is an inhibitor of the motility of intact human sperm at physiological concentration. These observations suggest that the roles played by Sg I and zinc on sperm motility are not mechanical but physiological.

Study in Bangladesh shows zinc is an essential element in male fertility

Bergdahl, Niels Henrik I. The effects of zinc, magnesium and calcium in seminal plasma on time-to-pregnancy TTP in healthy couples, on conventional semen parameters and computer-assisted semen analysis CASA parameters were evaluated. The localization of chelatable zinc ions in seminal plasma and spermatozoa were assessed by autometallography AMG. Differences in chelatable zinc localization in samples with high and low total zinc were evaluated.
Zinc is an essential mineral, but our understanding of its uses in the body is limited. Capitalizing on approaches available in the model system Caenorhabditis elegans , Zhao and colleagues show that zinc transduces a signal that induces sperm to become motile. This is an enigmatic process because sperm in all sexually-reproducing animals are transcriptionally inactive. Zinc levels inside sperm are regulated by an evolutionarily conserved zinc transporter called Zrt- and Irt-like Protein Transporter 7.
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